Season the venison and place a large heavy-based pan over a medium heat. Add the meat and brown it all over. Once coloured, add 100g/3½ oz of the cep butter and use it to baste the meat until cooked to your liking. Allow to rest.

Introducing our Cep Powder, a culinary delight that brings the rich, earthy flavours of wild forest mushrooms straight to your kitchen. The SEM images of the cepharanthine dry powder inhaler according to different treatment methods. ( A) Cepharanthine (scale bar = 60 μm); ( B) Cepharanthine API light-proof grinding (scale bar = 6 μm); ( C) Cepharanthine acetate solution alone freeze-dried (scale bar = 20 μm); ( D) Cepharanthine: Mannitol = 1:1 freeze-dried (scale bar = 6 μm); ( E) Cepharanthine: Mannitol = 1:2 freeze-dried (scale bar = 20 μm); ( F) Cepharanthine: Mannitol = 1:3 freeze-dried (scale bar = 20 μm); ( G) Cepharanthine: Mannitol = 1:5 freeze-dried (scale bar = 20 μm); ( H) Cepharanthine: Lactose = 1:5 freeze-dried (scale bar = 60 μm). Newman, S.P. Fine Particle Fraction: The Good and the Bad. J. Aerosol Med. Pulm. Drug Deliv. 2022, 35, 2–10. [ Google Scholar] [ CrossRef] Herridge, M.S.; Moss, M.; Hough, C.L.; Hopkins, R.O.; Rice, T.W.; Bienvenu, O.J.; Azoulay, E. Recovery and Outcomes after the Acute Respiratory Distress Syndrome (ARDS) in Patients and Their Family Caregivers. Intensive Care Med. 2016, 42, 725–738. [ Google Scholar] [ CrossRef] [ PubMed]Yasuda, K.; Moro, M.; Akasu, M.; Ohnishi, A. Pharmacokinetics of Cepharanthin in phase I clinical trials (single and continuous intravenous administration). Clin. Pharmacol. 1989, 20, 741–749. [ Google Scholar] [ CrossRef] Delicately remove the crispy pastry from around the metal cylinders and reserve in a cool, dry space before ready to plate. Ceps, dried or fresh, will lift any mushroom dish to a new level. Even a small amount added to other mushrooms can make quite a difference. Here are some of my favourite recipes – but be sure to try them raw in the forest first!

Ecology –Ceps are Mycorrhizal fungi, working with their tree partners by helping in their uptake of water, phosphorus, nitrogen and zinc in return for energy from photosynthesis in the form of sugars. Carbon sequestration by fungi is often an overlooked area of climate science. Ceps, and boletus species in general, can be important food and habitat to insects, slugs, rodents and I’ve even heard of deer nibbling on them. This fascinating paper shows that individual mushroom species can have specific relationships with individual insect species. In the case of ceps, (mostly) flies of the pegomya genus, and (some) fungal gnats of Sciaridae family use them as food home & nursery for their larvae. It has been postulated that insects could play a role in the reproductive strategies of some fungi (beyond the obvious stinkhorns) and who knows what other useful interactions they have with complex fungal lifecycles? The evolution of veils/rings ( annulus), webs ( cortina) and slime on the underside of some mushroom species is a direct defence to deter insects before spores have matured. Some slow growing fungi such as chanterelles deter insects chemically ( read the science of this here). That ceps have evolved no such strategy suggests to me that they they are happy partners with insects as well as trees! It seems likely that their very aromatic deliciousness has evolved to attract insects… And maybe humans too? Ceps can also play host to other fungi, notably the bolete eater fungus Hypomyces chrysospermus, and appear to have complex relationships with Fly agaric ( amanita mascaria), the miller ( Clitopilus prunulus) and peppery boletes ( Chalciporus piperatus) – more on which below. There has, of course, been innovation. All hail Ottolenghi. Likewise, new generations of cooks have arrived in waves, fully aware that the diverse traditions of the Indian subcontinent, of China and the Middle East and all points in between often get along just fine without reaching for an ingredient that once had a pulse. Give thanks, too, for the rich blessing that is miso; for the uncompromising heft of gochujang. Reiss, L.K.; Uhlig, U.; Uhlig, S. Models and Mechanisms of Acute Lung Injury Caused by Direct Insults. Eur. J. Cell Biol. 2012, 91, 590–601. [ Google Scholar] [ CrossRef] Choi, I.-W.; Sun-Kim; Kim, Y.-S.; Ko, H.-M.; Im, S.-Y.; Kim, J.-H.; You, H.-J.; Lee, Y.-C.; Lee, J.-H.; Park, Y.-M.; et al. TNF-Alpha Induces the Late-Phase Airway Hyperresponsiveness and Airway Inflammation through Cytosolic Phospholipase A(2) Activation. J. Allergy Clin. Immunol. 2005, 116, 537–543. [ Google Scholar] [ CrossRef] Wild porcini powder, or cep powder, brings an instant flavour boost to your cooking. You don't even have to worry about the rehydration process you would usually need to follow when cooking with dried mushrooms. The porcini powder brings a great way of enriching casseroles and soups with intense mushroom notes. Try it in risottos, marinades or rubbed straight into meat before cooking to infuse with savoury umami flavours.Azoulay, É.; Canet, E.; Raffoux, E.; Lengliné, E.; Lemiale, V.; Vincent, F.; de Labarthe, A.; Seguin, A.; Boissel, N.; Dombret, H.; et al. Dexamethasone in Patients with Acute Lung Injury from Acute Monocytic Leukaemia. Eur. Respir. J. 2012, 39, 648–653. [ Google Scholar] [ CrossRef] [ PubMed] Sous Chef is an independent family business that was started in 2012, with the desire to make high-quality, authentic world ingredients available to everyone. Cepharanthine (CEP) is a bis-benzylisoquinoline alkaloid isolated from plants of Stephania genus in 1934 ( 24). In 1937, the application of CEP enormously reduced the average mortality rate among patients with severe pulmonary tuberculosis from 41 to 22% at the Yokohama Sanatorium in Japan ( 25). But it has since been superseded by more effective drugs ( 26). Nonetheless, the initial successful clinical application of CEP in the treatment of tuberculosis has encouraged its utilization in other pathological indications, such as anti-inflammation, analgesia, anti-virus, and anti-tumor activity ( 27– 30). In the last few years, CEP has attracted increasing attention in research due to its distinct 1-benzylisoquinoline moiety similarities with natural polypeptides, physiological properties, and long-established remarkable safety profile ( 31). In December 2019, the emergence of the 2019 novel coronavirus disease (labeled COVID-19), caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has posed an unprecedented challenge to global public health. In a large drug screen of 2406 clinically approved drugs, CEP was recently identified as the most effective drug against SARS-CoV-2-related pangolin coronavirus. CEP has become a drug of interest for treating COVID-19 ( 31– 33). It is suggested that CEP is not a “one pill fits all” medication but certainly an under-explored drug which should be reconsidered ( 34). Increasing studies have indicated that CEP has a variety of pharmacological activities, implying that will play a crucial role in clinical trials. Nevertheless, CEP has the defect of low water solubility and low direct oral bioavailability which limit its pharmacological validity ( 35). The absolute bioavailability of CEP by oral route was only 5.65 ± 0.35% in rats ( 36). Therefore, it is urgent to explore effective means to boost oral bioavailability to meet the clinical needs of CEP.